Data on FTIR spectra of mixtures of sodium valproate (VPA) and histones H1 and H3




FTIR, Pharmacology, Sodium valproate (VPA), Histones


Valproic acid/sodium valproate (VPA), a drug primarily used for treatment of seizure disorders, is recognized as an efficient epigenetic agent, inducing inhibition of histone deacetylases, promoting changes in the methylation status of DNA and histones, and affecting chromatin structure. In addition to these epigenetic effects, molecular affinity of VPA for histone H1 has been proposed based on thermal denaturation, fluorescence spectroscopy and circular dichroism assays. VPA interactions with DNA and histones using Fourier transform infrared (FTIR) microspectroscopy and high-performance polarization microscopy that are not related to the effects promoted on epigenetic markers have been recently explored. Data in this article provide supplementary information for a better understanding of the resulting FTIR spectra for mixtures of VPA and histones H1 and H3 and of the potential effect of VPA directly on histones that has been reported in the literature.


DEEGAN, R.D. et al. Capillary flow as the cause of ring stains from dried liquid drops. Nature 389:827-829, 1997. DOI:

VIDAL, B.C.; MELLO, M.L.S. Sodium valproate (VPA) interactions with DNA and histones. Int J Biol Macromol 163:219-231, 2020. DOI: 10.1016/j.ijbiomac.2020.06.265.




How to Cite

MELLO, M. L.; VIDAL, B. Data on FTIR spectra of mixtures of sodium valproate (VPA) and histones H1 and H3. Latin American Data in Science, [S. l.], v. 1, n. 3, p. 102–109, 2022. DOI: 10.53805/lads.v1i3.36. Disponível em: Acesso em: 13 apr. 2024.